Physiology

Drug Receptor Interactions

Drug Receptor Interactions

ByNaplex Study Reading Time: 4 minutes

A. Drug–receptor binding At a fundamental level, drug molecules interact with specific receptors in order to produce the ultimate pharmacological effect. This interaction may be governed by the formation of hydrogen, ionic, or van der Waals bonds between given drug–receptor pairs. In general, these types of bonds are relatively weak and allow for the dissociation…

Cell Surface Receptors and Their Signal Transduction

Cell Surface Receptors and Their Signal Transduction

ByNaplex Study Reading Time: 4 minutes

1. The seven transmembrane G protein–coupled receptors They are localized in the plasma membranes of cells in such a manner as to have seven transmembrane domains, with multiple extracellular and intracellular domains. This group of receptors is the most heterogeneous of the cell surface receptors and communicates with intracellular components by activating specific guanine nucleotide-…