NAPLEX Calculation Practice (Part-2)

A physician orders midazolam hydrochloride (VERSED) 2 mg IV Stat. A pharmacist delivers a vial containing midazolam hydrochloride 5 mg/mL. How many milliliters should be administered?

A solution contains 10 mg/100 mL of Ca++ ions. Express this concentration in terms of milliequivalents per liter.

Copy - Copy - A new cephalosporin antibiotic was given at a dose of 5 mg/kg by a single intravenous bolus injection to a 58-year-old man who weighed 75 kg.
The antibiotic follows the pharmacokinetics of a one compartment model and has an elimination half-life of 2 hrs. The apparent volume of distribution is 0.28 L/kg, and the drug is 35% bound to plasma proteins. How long after the dose is exactly 75% of the drug eliminated from the patient’s body?

Copy - A new cephalosporin antibiotic was given at a dose of 5 mg/kg by a single intravenous bolus injection to a 58-year-old man who weighed 75 kg.
The antibiotic follows the pharmacokinetics of a one compartment model and has an elimination half-life of 2 hrs. The apparent volume of distribution is 0.28 L/kg, and the drug is 35% bound to plasma proteins. What is the predicted plasma drug concentration (Cp) at 8 hr after the dose?

A new cephalosporin antibiotic was given at a dose of 5 mg/kg by a single intravenous bolus injection to a 58-year-old man who weighed 75 kg.
The antibiotic follows the pharmacokinetics of a one compartment model and has an elimination half-life of 2 hrs. The apparent volume of distribution is 0.28 L/kg, and the drug is 35% bound to plasma proteins. What is the initial plasma drug concentration in this patient?

Determine the creatinine clearance rate for an 80-year-old male patient weighing 70 kg and having
a serum creatinine of 2 mg/dL. [Use Cockcroft-Gault equations]

A patient weighing 80 kg was given an initial bolus dose of heparin and a heparin drip for the first 6 hours. Using Figure 10.1 and the low-dose heparin protocol, what was the total amount of heparin administered in this period?

A biologic contains 50 Lf Units of diphtheria toxoid in each 2.5 mL of product. If a pediatric patient is to receive 10 Lf Units, how many milliliters of product should be administered?

If neomycin sulfate has a potency of 600 g of neomycin per milligram, how many milligrams of neomycin sulfate would be equivalent in potency to 1 mg of neomycin?

How many milliliters of a heparin sodium injection containing 200,000 units in 10 mL should be used to obtain 5,000 Heparin Sodium Units that are to be added to an intravenous dextrose solution?

If the adult dose of a drug is 100 mg, calculate the approximate dose for a child with a BSA of 0.83 m2.

The usual initial dose of chlorambucil is 150 mcg/kg of body weight. How many milligrams should be administered to a person weighing 154 lb.?

How many grams of a drug substance are required to make 120 mL of a solution each teaspoonful of which contains 3 mg of the drug substance?

If 0.050 g of a substance is used in preparing 125 tablets, how many micrograms are represented in each tablet?

If the dose of a drug is 200 mg, how many doses are contained in 10 g?

If 5 g of boric acid is added to 100 mL of water, what is the percentage strength (w/w) of the solution?

How many grams of a drug substance should be added to 240 mL of water to make a 4% (w/w) solution?

Peppermint spirit contains 10% v/v of peppermint oil. What volume of the spirit will contain 75 mL of peppermint oil?

What is the percentage strength v/v of a solution of 800 g of a liquid with a specific gravity of 0.800 in enough water to make 4000 mL?

How many milliliters of a 3% solution can be made from 27 g of ephedrine sulfate?

What is the percentage strength (w/v) of a solution of urea, if 80 mL contains 12 g?

How many grams of dextrose are required to prepare 4000 mL of a 5% solution?

What is the specific volume of phosphoric acid having a specific gravity of 1.71?

What is the cost of 1000 mL of glycerin, specific gravity 1.25, bought at $54.25 per pound?

What is the volume, in milliliters, of 492 g of nitric acid with a specific gravity of 1.40?