A. Drug–receptor binding At a fundamental level, drug molecules interact with specific receptors in order to produce the ultimate pharmacological effect. This interaction may be governed by the formation of hydrogen, ionic, or van der Waals bonds between given drug–receptor pairs. In general, these types of bonds are relatively weak and allow for the dissociation…
Xenobiotics, whether they are drugs or not, can influence the activity of drug-metabolizing enzymes in a variety of ways. Inducers: are xenobiotics that cause an increase in the drug-metabolizing activity of a target enzyme, usually by increasing the concentration of the enzyme in the liver or other tissue. Several CYP450 enzymes and glucuronosyltransferases…
CYP450 enzymes are involved in many drug-drug interactions. Some drugs can inhibit or induce the activity of these enzymes, leading to altered metabolism of co-administered drugs. CYP1A2 CYP2C9 CYP2C8 CYP2C19 CYP2D6 CYP2E1 CYP3A family Read also:
Many interactions between tobacco smoke and medications have been identified. Tobacco smoke interacts with medications by influencing the absorption, distribution, metabolism, or elimination of other drugs, potentially causing an altered pharmacologic response. Read also: